Which route of pesticide exposure is the most concerning for handlers?

The concern regarding the route of pesticide exposure for handlers notably hinges on the dermal route. Pesticides can be easily absorbed through the skin, which is a large surface area, especially considering that handlers may not always wear protective gear adequately. This route of exposure can result in significant absorption of the chemical directly into the bloodstream, leading to systemic effects and potential harm.

Additionally, certain pesticides are designed to penetrate biological membranes, and if they are not handled with care, it increases the risk of absorption through the skin. Factors such as the specific formulation of the pesticide, the duration of contact, and even the condition of the skin (e.g., cuts or abrasions) can further exacerbate this risk. While all routes of exposure—oral, inhalation, ocular, and dermal—are of concern, the dermal route stands out due to its high potential for absorption and the frequency with which handlers may inadvertently expose themselves, especially in agricultural settings.